oncogene
The activated form of a proto-oncogene. Mechanisms by which proto-oncogenes become activated include transduction by a retrovirus, mutation, and chromosomal translocation whereby the proto-oncogene is placed into a new genetic environment.
vav-1 oncogene
A rho-type guanine nucleotide exchange factor (GEF) of the Dbl family. vav-1 plays a role in development and activation of T and B cells. vav- 1 is the binding partner of the HIV-1 nef proteins. The vav-1/nef complex causes cytoskeletal rearrangements, activates the JNK/SAPK signaling cascade, and upreg- ulates HIV transcription and replication. The vav gene map locus is 19p13.2